Interpretable multimodal MRI radiomics for predicting neoadjuvant chemotherapy response in nasopharyngeal carcinoma

Tian Cheng-lin; Kai Jie Wang; Wen Zhu Li; Gang Wu; Feng Chen; Wei-Yuan Huang

doi:10.1186/s12880-025-02071-8

November 25, 2025BMC Medical ImagingOpen Access

Interpretable multimodal MRI radiomics for predicting neoadjuvant chemotherapy response in nasopharyngeal carcinoma

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Key Points

The multimodal MRI radiomics model predicts neoadjuvant chemotherapy response effectively in nasopharyngeal carcinoma.
Combining different MRI techniques, including DCE-MRI, enhances prediction accuracy and clinical relevance in NPC.
SHAP analysis demonstrates the interpretability of the radiomics model, aiding clinician understanding of results.
This approach highlights the potential for improved therapeutic strategies based on pre-treatment imaging evaluations.

Implication

Observational analysis predicts neoadjuvant chemotherapy response in nasopharyngeal carcinoma, indicating multimodal MRI radiomics may enhance clinical decision-making.

Abstract

The multimodal MRI radiomics model, especially when combined with DCE-MRI, can effectively predict NAC response in NPC patients. The model's interpretability through SHAP analysis demonstrates its potential for clinical application.

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Cite This Study

Cheng-lin et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a099 https://doi.org/10.1186/s12880-025-02071-8

View Full Paper

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Interpretable multimodal MRI radiomics for predicting neoadjuvant chemotherapy response in nasopharyngeal carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Interpretable multimodal MRI radiomics for predicting neoadjuvant chemotherapy response in nasopharyngeal carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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