Single-cell RNA sequencing revealed the association between proximal tubular epithelial cells and renal interstitial cells in chronic kidney disease progression
Observational analysis reveals interactions between proximal tubular epithelial cells and macrophages in chronic kidney disease, suggesting new targets.
Key Points
CKD progression correlates with the activity of macrophages, indicating their role in disease severity.
Serum creatinine and blood urea nitrogen levels were elevated, marking significant renal damage during the study.
Single-cell RNA sequencing was utilized to map cellular distinctions and interactions during chronic kidney disease development.
Findings underscore the potential therapeutic targets related to interstitial remodeling and inflammation in CKD.