Differential impact of sex and age on the obesity paradox: A retrospective observational study of a binational registry

November 24, 2025Australian Critical CareOpen Access

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Key Points

Obesity paradox is significantly pronounced, particularly among older men, indicating age and sex modify its impact.
Analysis of historical health data shows that age further influences the relationship between body weight and health outcomes.
Observational analysis within a binational registry examined variations in obesity paradox across demographics and age groups.
Findings highlight the importance of considering age and sex in obesity-related health assessments.

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Retrospective observational study reveals that the obesity paradox is amplified in older men, suggesting demographic factors influence outcomes.

The obesity paradox is modified by both sex and age. The paradox is more pronounced for men and within the group of older patients.

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Plecko et al. (2025) studied this question.

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