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November 28, 2025Scientific ReportsOpen Access

Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury

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Authors

LBL. BoutinSFS. M. FigueroaERE Roger

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Overview

Analysis reveals Galectin-3 promotes endothelial activation and inflammation in acute kidney injury via CD146 interactions.

Key Points

  • Galectin-3 significantly increased systemic inflammation after acute kidney injury, enhancing renal damage and immune cell infiltration.
  • Immunofluorescence and plasma proteomics determined Galectin-3 plays a key role in endothelial activation during renal ischemic injury.
  • Bone marrow transplantation in mice indicated that Galectin-3 expression in renal tissue worsens kidney dysfunction and inflammation post-reperfusion.
  • Intervention with recombinant Galectin-3 elevated CD146 levels but did not cause additional renal injury, suggesting targeted pathways for treatment.

Cite This Study

Boutin et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a44fhttps://doi.org/10.1038/s41598-025-25477-4
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