Assessment using photostimulation improves neuroimmune responses in SAE mice, indicating potential for non-invasive interventions.
We demonstrate that 50 mW IR can be safely confined to the SBM, effectively modulating skull, meningeal, and brain immunity to protect neurons in SAE mice. This study establishes SBM-restricted IR photobiomodulation as a safe and effective strategy to reprogram neuroimmune responses, highlighting the SBM-DM-B Axis as a novel pathway for neuroimmune regulation and a promising target for non-invasive interventions in SAE and other acute brain injuries.
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Li et al. (2025) studied this question.
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