We demonstrate that 50 mW IR can be safely confined to the SBM, effectively modulating skull, meningeal, and brain immunity to protect neurons in SAE mice. This study establishes SBM-restricted IR photobiomodulation as a safe and effective strategy to reprogram neuroimmune responses, highlighting the SBM-DM-B Axis as a novel pathway for neuroimmune regulation and a promising target for non-invasive interventions in SAE and other acute brain injuries.
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Du et al. (2025) studied this question.
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