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Targeted Cascade Genetic Testing in Korean Prostate Cancer Probands: High Detection Rate of Heritable Germline Variants in First-Degree Relatives From a Retrospective Cohort

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Over half of first-degree relatives tested carried pathogenic germline variants, indicating significant hereditary risk.
17.5% of relatives declined genetic testing, primarily due to concerns about privacy and travel distances.
Retrospective cohort study reviewed records of prostate cancer patients and their eligible family members.
Highlights the importance of participation in familial genetic screening to manage prostate cancer risk.

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Retrospective analysis shows over 51% of first-degree relatives carry mutations, highlighting the need for enhanced genetic screening.

Song et al. (2025) studied this question.

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