CD8 + T Cell Cytotoxicity and Exhaustion Underlie Liver Allograft Rejection: Insights From a Murine Transcriptomic Atlas

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Discussion

Observational analysis reveals immune tolerance pathways in liver transplantation, indicating a role for T cell exhaustion.

Liver transplantation rejection is associated with T cell exhaustion and increased granzyme-B levels in CD8+ T cells.
A total of 2560 DEGs were identified, highlighting molecular interplay in graft-versus-host disease and cytokine signaling pathways.
Transcriptomic analysis shows significant decreases in IL2RA and TNF in the immune tolerance group, indicating altered immune responses.
Findings may enable targeted therapies to improve outcomes in liver transplantation, focusing on T cell dynamics and exhaustion.

Jiang et al. (2025) studied this question.

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