Anti‐Inflammatory Jatrophane Diterpenoids With Multiple Chiral Carbon Centers From Jatropha curcas

Two previously undescribed jatrophane‐type diterpenoids ( 1 , 2 ) and 11 known compounds ( 3 – 13 ) were isolated from the whole plants of Jatropha curcas L. Their structures were elucidated using IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra, and the absolute configurations were established by ECD. The anti‐inflammatory activity of these compounds was evaluated by inhibiting NO production in LPS‐stimulated RAW264.7 macrophages, and compounds 5 , 8 – 11, and 13 showed potent activity with IC 50 values ranging from 16.86 to 32.49 μM, which were comparable with that of the positive control l ‐NMMA (IC 50 : 21.90 μM). The structure–activity relationships of jatrophane‐type diterpenoids revealed that compounds 5 and 11 showed the most potent anti‐inflammatory effects.