Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study

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MGUS is associated with 29.5% 10-year cardiovascular disease incidence compared to 9.7% in non-MGUS individuals, showing a significant increase in risk.
The study involved 70,320 individuals from a Veterans Health Administration cohort, highlighting the scale of the findings.
Cumulative incidence functions were compared using Gray's test, underpinning the analytical approach for assessing MGUS and cardiovascular disease risk.
These findings indicate MGUS as a clinical utility marker for cardiovascular disease risk assessment in adults.

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Retrospective analysis shows MGUS raises cardiovascular disease risk in veterans, suggesting its prognostic value beyond standard assessments.

Michaud et al. (2025) studied this question.

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Retrospective analysis shows MGUS raises cardiovascular disease risk in veterans, suggesting its prognostic value beyond standard assessments.