Modular continuous flow synthesis of Zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing

Yan Chen; Rongkun Jiang; Fang Zhao; Yufang Xu; XU Hong-qian; Weiping Zhu

doi:10.1039/d5re00370a

November 26, 2025Reaction Chemistry & Engineering

Modular continuous flow synthesis of Zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing

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Key Points

Enhanced sustainability addresses challenges in HIV drug manufacturing, improving environmental impact.
Key findings suggest a modular synthesis process that optimizes azidation methods, yielding better safety.
This research utilized continuous flow synthesis to refine the production of zidovudine as an HIV treatment.
Implications highlight the importance of sustainable practices in pharmaceutical manufacturing to combat epidemics.

Implication

Analysis reveals enhanced sustainability in zidovudine production for antiretroviral therapy, suggesting safer methods.

Abstract

AIDS is one of the deadliest global epidemics. Zidovudine (AZT), the first FDA-approved HIV treatment, is a key component of antiretroviral therapy. The current industrial synthesis of AZT exhibits several...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a37840e https://doi.org/10.1039/d5re00370a

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Modular continuous flow synthesis of Zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing

Key Points

Implication

Abstract

Discussion

Cite This Study

Modular continuous flow synthesis of Zidovudine (AZT): a two-stage integrated process enabling safe azidation and enhanced sustainability in HIV drug manufacturing

Key Points

Implication

Abstract

Discussion

Cite This Study

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