Development of Modern Continuous Flow Solid Phase Peptide Synthesis: Chemistry, Automation and Sustainability Impact

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Mini-review highlights continuous flow methods enhancing automation and environmental impact in solid phase peptide synthesis.

Reaction kinetics improved significantly with continuous flow methodologies, enhancing peptide synthesis efficiency.
The integration of flow chemistry with solid phase techniques revolutionizes instrumentation used for peptide production.
Automation and sustainability are key benefits of the continuous flow solid phase peptide synthesis process.
Next-generation polymer supports may resolve limitations faced with batch process-dependent solid supports.

Wellings et al. (2025) studied this question.

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