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November 30, 2025European Journal of Organic ChemistryOpen Access

Expeditious Synthesis of Pyrano2,3,4‐ de quinolines by a Copper(I)‐Catalyzed Cascade Sonogashira Coupling/Annulation Reaction

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Authors

AMAnirban MandalPGPrasanjit GhoshSDSajal Das

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Overview

Copper(I)‐catalyzed coupling yields high-value pyranoquinoline scaffolds, suggesting improvements in medicinal chemistry.

Key Points

  • Pyranoquinoline scaffolds are synthesized efficiently, providing promising yields.
  • This coupling method includes a broad substrate scope for various internal alkynes.
  • Utilizing a copper(I)‐catalyzed approach helps achieve good functional-group compatibility.
  • This methodology may enhance the development of complex medicinal chemistry targets.

Cite This Study

Mandal et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a3785fchttps://doi.org/10.1002/ejoc.202500612
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expeditious Synthesis of Pyrano[2,3,4‐ <i>de</i> ]quinolines by a Copper(I)‐Catalyzed Cascade Sonogashira Coupling/Annulation Reaction2025
  2. 2Base‐Promoted Annulation for the Synthesis of Functionalized Isoxazole‐Linked 1,4‐Dihydropyrazolo[4′,3′:5,6]pyrano[2,3‐ <i>b</i> ] Quinolines2026
  3. 3Silver(I)-Promoted [3 + 3]-Cycloaddition of 2-(2-Enynyl)quinolines with <i>N</i>′-(2-Alkynylbenzylidene)hydrazides2024
  4. 4Cascade Synthesis of Pyridoquinazolinones: A Pd-Catalyzed Double C–N Bond Formation Strategy via Intramolecular 1,6-Conjugate Addition2026
  5. 5Tandem Synthesis of 3,5‐Dihydrocyclopenta[de]quinolin‐2(1H)‐one Scaffolds from α‐Bromocarbonyls and α‐Diazoesters under Copper and Palladium Catalysis2024 · 1 citations