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Synthetic study demonstrates efficient one-pot synthesis of pyridoquinazolinones via palladium catalysis, highlighting step economy and open-air conditions.
A cascade process has been designed to access pyridoquinazolinone derivatives through a Pd-catalyzed annulation reaction between readily accessible 2-bromo-p-quinone methides and commercially available 2-aminopyridines. This one-pot process comprises Pd-catalyzed C–N bond formation, followed by a second C–N bond formation through intramolecular 1,6-conjugate addition, affording the various functionalized pyridoquinazolinones in good yields. This synthetic method has several advantages, including step economy, broad substrate scope, and an open-air reaction.
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Saikia et al. (2026) studied this question.
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