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November 30, 2025Advanced Healthcare Materials

Lipid Droplets‐Targeted Thermally Activated Delayed Fluorescence Photosensitizer for Photodynamic Therapy‐Mediated Ferroptosis: a New Strategy for Tumor Radiosensitization

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Authors

SXShengnan XuXWXiang WangKPKeru Pu

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Overview

Photosensitizer enhances ferroptosis and ROS production in radioresistant tumors, suggesting new radiosensitizer strategies.

Key Points

  • Ferroptosis improves radiosensitivity by targeting lipid droplets in cancer cells, enhancing treatment efficacy.
  • The photosensitizer generates reactive oxygen species, inducing lipid peroxidation in radioresistant A549 cells.
  • Assessed through photodynamic therapy, this approach demonstrates potential for overcoming tumor radioresistance.
  • This strategy highlights the role of lipid metabolism in developing next-generation radiosensitizers.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/692b943e1d383f2b2a378909https://doi.org/10.1002/adhm.202504496
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipid Droplets‐Targeted Thermally Activated Delayed Fluorescence Photosensitizer for Photodynamic Therapy‐Mediated Ferroptosis: a New Strategy for Tumor Radiosensitization2025
  2. 2Cell Membrane‐Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis‐Enhanced Photodynamic Immunotherapy2024 · 19 citations
  3. 3Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy2024 · 26 citations
  4. 4Lysosome-Targeted Iridium(III) Photosensitizers Activate the Mitophagy−Ferroptosis Axis to Boost Two-Photon Photoimmunotherapy Against Hypoxic Cisplatin-Resistant Tumors2026
  5. 5Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors2024 · 6 citations