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November 30, 2025PLoS ONEOpen Access

CanRisk-GP protocol: A feasibility study of incorporating proactive multifactorial breast cancer risk assessment into general practice

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Authors

FDFrancisca Stutzin DonosoSAStephanie ArcherFWFiona M. Walter

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Overview

Feasibility study reports that integrating multifactorial breast cancer risk assessment improves identification of high-risk women in general practice, suggesting better management options.

Key Points

  • Women at above-population level risk were identified through multifactorial breast cancer risk assessment, enhancing early intervention opportunities.
  • The feasibility study engaged women aged 40–49 years across Cambridgeshire, testing the CanRisk tool for effective risk reporting.
  • Incorporation of polygenic scores and comprehensive risk factors was crucial to assess women's risks and manage referrals accordingly.
  • Potentially beneficial for expanding access to risk-reducing options for women in general practice settings.

Cite This Study

Donoso et al. (2025) studied this question.

synapsesocial.com/papers/692b943e1d383f2b2a378aa8https://doi.org/10.1371/journal.pone.0336902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CanRisk-GP protocol: A feasibility study of incorporating proactive multifactorial breast cancer risk assessment into general practice2025
  2. 2Acceptability of breast cancer risk assessment amongst general population women aged 30-39 years: a qualitative study2026
  3. 3Priorities for breast cancer risk assessment in UK women under age 50: a survey and discrete choice experiment2026
  4. 4The feasibility of risk-stratified screening as routine practice in the NHS Breast Screening Programme in England: the PROCAS2 research programme2025
  5. 5Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities2024 · 23 citations