Iron-catalyzed reaction generates terminal alkenes from thioketals, suggesting a new approach to sulfur chemistry.
A novel iron-catalyzed reaction has been developed for the preparation of various vinyl sulfides. This new method enables a range of thioketals to easily access terminal alkenes featuring different alkylthio groups. 28 sulfanes have been efficiently achieved with moderate to good yields. A preparative-scale reaction also proceeds well, demonstrating its further potential in organic synthesis. We further tried to understand its mechanism by DFT calculations. This methodology is significant in sulfur chemistry, giving a new pathway to transform thioketals to vinyl sulfides.
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Wang et al. (2025) studied this question.
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