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November 30, 2025Journal of Neurogenetics

A cell-autonomous role for the vitamin B6 metabolism gene PNPO in Drosophila GABAergic neurons

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Authors

WFWenqin FuSLSaul LandaverdeXZXiaoxi Zhuang

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Overview

Expression of human PNPO in GABAergic neurons reduces seizures and improves lifespan in Drosophila, highlighting its critical role.

Key Points

  • Lifespan improved significantly with human PNPO in GABAergic neurons, while seizures decreased.
  • GABA receptor modulation led to variable outcomes on survival, with the agonist SKF-97541 showing benefits.
  • Analysis of sugarlethal mutants demonstrated notable phenotypes influenced by dietary vitamin B6 restrictions.
  • This cell-autonomous finding suggests targeted therapies for neurological conditions related to PNPO deficiency.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/692b944c1d383f2b2a378ca7https://doi.org/10.1080/01677063.2025.2591617
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