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November 30, 2025Journal of Translational MedicineOpen Access

Spatial omics in 3D culture model systems: decoding cellular positioning mechanisms and microenvironmental dynamics

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Authors

LDLiwei DuHYHuayu YangLDLiwei Du

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Overview

Review highlights how spatial omics and 3D culture systems demonstrate tumor microenvironment impacts on gene expression and therapeutic resistance.

Key Points

  • Tumor microenvironment affects gene expression and therapeutic resistance, enhancing understanding of cancer dynamics.
  • Spatial omics methods provide high-resolution insights into gene expression across organoids and 3D bioprinting constructs.
  • Integration of multimodal datasets enables mapping of cell interactions within microenvironmental contexts.
  • Advancements in imaging and analysis techniques promise to improve disease modeling and personalized treatment strategies.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/692b944c1d383f2b2a378cd3https://doi.org/10.1186/s12967-025-07390-6
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