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November 30, 2025MedicineOpen Access

Clinical and pathological features of antinuclear antibody-positive drug-induced liver injury compared with autoimmune hepatitis: A retrospective study

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Authors

WLWanting LiuZZZhendong ZhangXMXiaohan Ma

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Overview

Retrospective study reveals liver function and histopathological differences in ANA-positive drug-induced liver injury compared to autoimmune hepatitis.

Key Points

  • ANA-positive drug-induced liver injury group showed lower immunoglobulin levels and higher total bilirubin than autoimmune hepatitis.
  • Women had a significantly higher detection rate of antinuclear antibodies in liver injury cases.
  • Retrospective analysis of 87 drug-induced liver injury and 82 autoimmune hepatitis cases revealed diagnostic challenges.
  • Differences in liver inflammation suggest a need for careful differentiation in clinical settings.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/692b944c1d383f2b2a378e35https://doi.org/10.1097/md.0000000000045750
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Also Consider

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  3. 3Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models2021 · 80 citations
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  5. 5Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective <scp>DILI</scp> registries2023 · 31 citations