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November 30, 2025MedicineOpen Access

Effective components of Coptidis Rhizoma and Cinnamomi Cortex in the treatment of renal cell carcinoma and their mechanism of action

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Authors

DDDongmei DuanJWJin WangMCMingjun Chen

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Implication

Network pharmacology reveals that HL-RG lowers targets in renal cell carcinoma, indicating its potential to improve treatment outcomes.

Key Points

  • HL-RG combination demonstrated therapeutic effects against renal cell carcinoma, regulating inflammation and metabolic processes.
  • Analysis highlighted network pharmacology as a key method with 42 active components identified in HL-RG.
  • Cell experiments validated molecular docking predictions, reinforcing the role of tetrandrine against RCC.
  • Potential significance lies in modulating critical pathways like HIF-1 to enhance therapeutic effects in RCC cases.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/692b94581d383f2b2a378e67https://doi.org/10.1097/md.0000000000043786
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