November 30, 2025Journal of Human ImmunityOpen Access

White, Blue, Red…and Something Else

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Case report highlights diagnostic challenges in worsening symptoms of Raynaud’s, suggesting potential systemic disease.

Progressive digital symptoms occurred in a patient with longstanding Raynaud’s phenomenon, indicating serious underlying issues.
Diagnostic investigation revealed unexpected systemic diagnosis amid absent connective tissue disease features.
Routine clinical examinations and imaging failed to identify the cause of worsening symptoms, complicating the diagnosis.
This case emphasizes the importance of reevaluating symptoms in known conditions to uncover less common pathologies.

A 2025 study studied this question.

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