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November 30, 2025BiomoleculesOpen Access

Embryological Divergence and Molecular Mechanisms in Thoracic and Abdominal Aortic Aneurysms: Bridging Developmental Biology and Clinical Insights

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Authors

MHMathias Van HemelrijckPRPetar RisteskiLRLaura Rings

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Overview

Narrative review highlights molecular mechanisms and their role in aneurysm risk stratification and clinical outcomes.

Key Points

  • Aortic aneurysms show distinct patterns of incidence with thoracic types rising and abdominal types declining, indicating varying risk profiles.
  • Key findings reveal that inflammation and oxidative stress are critical molecular mechanisms in aneurysm development and progression.
  • The assessment included a narrative review of literature, emphasizing the significance of cellular heterogeneity and phenotypic switching in aneurysms.
  • This research highlights the importance of risk stratification and genomic technologies for personalized management strategies in patients.

Cite This Study

Hemelrijck et al. (2025) studied this question.

synapsesocial.com/papers/692b94601d383f2b2a379181https://doi.org/10.3390/biom15121654
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Embryological Divergence and Molecular Mechanisms in Thoracic and Abdominal Aortic Aneurysms: Bridging Developmental Biology and Clinical Insights2025
  2. 2Ascending Aortic Aneurysms: From Pathophysiology to Surgical Repair2025 · 3 citations
  3. 3The Expanding Genetic Architecture of Arteriopathies: From Canonical TAAD Genes to Emerging Connective Tissue and Signaling Pathways2025 · 8 citations
  4. 4Mechanisms Driving Thoracic Aortic Aneurysm Stability2025 · 1 citations
  5. 5Editorial: Molecular advances and new insights in aortic aneurysmal diseases2026