Newly developed palladium complexes featuring ONS donor ligands: Synthetic method, characterization, CT-DNA, BSA protein binding study and in-vitro cytotoxicity

Arpan Halder; Akash Das; Tapan Kumar Mondal; Subhabrata Guha; Gaurav Das; Rahul Naskar

doi:10.1039/d5nj03343h

January 1, 2025New Journal of Chemistry

Newly developed palladium complexes featuring ONS donor ligands: Synthetic method, characterization, CT-DNA, BSA protein binding study and in-vitro cytotoxicity

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Key Points

Synthesis and characterization of palladium complexes emphasize imine donor ligands for improved efficacy.
The complexes were tested for in-vitro cytotoxicity against cancer cells, revealing promising activity.
Characterization involved advanced spectroscopic and analytical techniques to confirm ligand binding.
Future work may focus on clinical relevance given the observed cytotoxicity in vitro.

Implication

Observational analysis showcases imine-functionalized palladium complexes indicating potential cytotoxicity effects.

Abstract

Two new palladium(II) complexes (C1 and C2) were synthesized using imine- and azo-functional ligands, namely (E)-4-hydroxy-3-(1-((2-(methylthio)phenyl) imino)ethyl)-2H-chromen-2-one (HL1) and (E)-6-((2-(ethylthio)phenyl)diazenyl)-7-hydroxy-4-methyl-2H-chromen-2-one (HL2). The ligands and their corresponding complexes were comprehensively characterized...

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Halder et al. (2025) studied this question.

synapsesocial.com/papers/692b9d831d383f2b2a379641 https://doi.org/10.1039/d5nj03343h

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Newly developed palladium complexes featuring ONS donor ligands: Synthetic method, characterization, CT-DNA, BSA protein binding study and in-vitro cytotoxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

Newly developed palladium complexes featuring ONS donor ligands: Synthetic method, characterization, CT-DNA, BSA protein binding study and in-vitro cytotoxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

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