Accurate Mass Differences of High Molecular Weight Unknown Compounds from Resolved Isotopic Distributions: Oligonucleotide Impurities

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Accurate mass differences accurately identify oligonucleotide impurities, enabling precise formula determination.
Determination of accurate mass differences employed techniques based on monoisotopic mass and combinatorial methods.
Data analysis of isotopic distributions provided insights into the complexities of high molecular weight compounds.
Improved methods may enhance identification, aiding in better understanding of oligonucleotide complexities.

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Analysis determines accurate mass differences in oligonucleotides, suggesting improved identification of HMW compounds.

Stilianos G. Roussis (2025) studied this question.

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