Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study
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Overview
Observational analysis demonstrated hyperandrogenism increases obesity risk in females, suggesting targeted health interventions may be necessary.
Key Points
Obesity risk is associated with hyperandrogenism in females, and testosterone appears protective in males.
Key findings reveal that hyperandrogenism correlates with increased adiposity measures in women, while testosterone shows a negative association with obesity.
Analysis utilized generalized additive models to assess relationships between sex hormones and obesity-related indicators across two gender groups.
These results may enable targeted obesity interventions based on hormonal profiles, especially among women with hyperandrogenism.