Controlling interactions between peptide-heme and G-quadruplex DNA using Fe-bound NH ₃ and H ₂ O ligands

doi:10.1039/d5qi02103k

November 27, 2025Inorganic Chemistry Frontiers

Controlling interactions between peptide-heme and G-quadruplex DNA using Fe-bound NH ₃ and H ₂ O ligands

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Key Points

G-quadruplex DNA stability improved by peptide-heme ligands, with significant implications for cancer therapy.
The study demonstrates increased stability through specific interactions with peptide-heme and ligands.
Assessment of the hybrid complex reveals potential for novel anticancer treatment strategies based on improved DNA structures.
These findings may enable further research into G-quadruplex DNA as a therapeutic target for cancer treatments.

Implication

Analysis shows improved stability of G-quadruplex DNA using peptide-heme ligands, suggesting new anticancer approaches.

Abstract

Developing ligands that improve the stability of G-quadruplex DNA (G4) is a promising anticancer strategy. We constructed a Peptide-Heme-NH 3 /G4 hybrid complex possessing a unique NH 3 axial ligand between the heme...

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A 2025 study studied this question.

synapsesocial.com/papers/692b9d931d383f2b2a379bfb https://doi.org/10.1039/d5qi02103k

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Controlling interactions between peptide-heme and G-quadruplex DNA using Fe-bound NH ₃ and H ₂ O ligands

Key Points

Implication

Abstract

Discussion

Cite This Study

Controlling interactions between peptide-heme and G-quadruplex DNA using Fe-bound NH ₃ and H ₂ O ligands

Key Points

Implication

Abstract

Discussion

Cite This Study

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