A Novel Zeolite–Carbon Nanotube Composite Electrode for the Electrochemical Analysis of Agomelatine in Real Samples

This study aimed to develop and apply a novel zeolite-modified electrode (ZME), integrating Cu-exchanged zeolite Y (Cu-ZY) with a conductive carbon matrix composed of multi-walled carbon nanotubes (MWCNTs), for the sensitive and selective voltammetric determination of agomelatine (AGO), an important antidepressant, the accurate determination of which in pharmaceutical and biological samples is critical for therapeutic monitoring and quality control. Drop-casting the Cu-ZY/MWCNTs composite onto the surface of a glassy carbon electrode (GCE) resulted in the formation of a unique sensing platform, which exhibited a significantly improved electrochemical response for the oxidation of AGO. The enhanced activity of Cu-ZY/MWCNTs-GCE, attributed to the synergistic combination of Cu-ZY and MWCNTs, was confirmed by morphological, textural, and voltammetric analyses. Differential pulse voltammetry (DPV) was utilized for the quantitative determination of AGO, with optimization performed on instrumental parameters, supporting electrolyte pH, and preconcentration time (tacc). Using the Britton–Robinson buffer (BRB) solution at pH 3.0, the Cu-ZY/MWCNTs-GCE exhibited a linear response to AGO concentrations ranging from 8.2 × 10−9–9.6 × 10−7 mol L−1 (0.002–0.23 mg L−1), achieving a detection limit (LOD) of 4.3 × 10−9 mol L−1 (1.04 µg L−1) with a preconcentration time of 60 s. The successful determination of AGO in pharmaceutical formulations, wastewater, and biological fluids, with recoveries ranging from 98.0 to 113.0%, demonstrates the effectiveness and practical applicability of the Cu-ZY/MWCNT-GCE-based voltammetric method for agomelatine analysis in complex matrices.