Responses of nasal polyp-derived macrophages to inflammatory cues and potential pathological roles in type 2 chronic rhinosinusitis with nasal polyps

Hyunkyung Cha; Ara Jo; Hee Suk Lim; Kyoung Mi Eun; Jin-A Park; Seung-No Hong; Dae Woo Kim

doi:10.21053/ceo.2025-00142

November 27, 2025Clinical and Experimental OtorhinolaryngologyOpen Access

Responses of nasal polyp-derived macrophages to inflammatory cues and potential pathological roles in type 2 chronic rhinosinusitis with nasal polyps

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Key Points

Chronic rhinosinusitis with nasal polyps may involve inflammatory macrophage responses.
Macrophages exhibited increased expression of inflammatory markers like TSLP and OSM.
Observational analysis highlights the potential pathophysiological role of macrophages in this condition.
The findings indicate the need for further studies on macrophage function in chronic rhinosinusitis.

Implication

Observational analysis reveals heightened macrophage activity in chronic rhinosinusitis with nasal polyps, suggesting an inflammatory role.

Abstract

NP-derived macrophages from T2 CRSwNP exhibit elevated expression of TSLP and OSM in response to IL-4 or SEB, potentially contributing to the pathophysiology of T2 CRSwNP.

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Cite This Study

Cha et al. (2025) studied this question.

synapsesocial.com/papers/692b9da01d383f2b2a37a346 https://doi.org/10.21053/ceo.2025-00142

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Responses of nasal polyp-derived macrophages to inflammatory cues and potential pathological roles in type 2 chronic rhinosinusitis with nasal polyps

Key Points

Implication

Abstract

Discussion

Cite This Study

Responses of nasal polyp-derived macrophages to inflammatory cues and potential pathological roles in type 2 chronic rhinosinusitis with nasal polyps

Key Points

Implication

Abstract

Discussion

Cite This Study

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