November 30, 2025Science AdvancesOpen Access

Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans

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Discussion

LMD-3 regulates proteostasis and oxidative stress in C. elegans, suggesting potential therapeutic strategies for fertility loss.

Cellular stress responses are significantly elevated in lmd-3 mutants, correlating with fertility decline.
LMD-3 protein influences lysosomal function through interactions with vitellogenin and ATPase.
Supplementation with vitamin B12 improves lysosomal function in lmd-3 mutants, enhancing reproductive capacity.
These findings highlight the conserved molecular pathways affecting fertility across species, implying therapeutic targets.

Zhai et al. (2025) studied this question.

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