High-fat diet-induced anorexia in rats: involving orosensory deficits, gastrointestinal dysfunction, intestinal taste receptor downregulation and dopamine signaling dysregulation

HFD consumption effectively induced anorexia in young rats, which was accompanied by gastrointestinal dysfunction, a reduction in taste buds, impaired gut-brain axis taste transduction and a suppressed central DA response. These results indicate that peripheral-central axis impairment may be an important pathological phenomenon in HFD-induced anorexia.