Medication-related osteonecrosis of the jaw in patient with McCune-Albright syndrome: A rare case report

McCune-Albright Syndrome (MAS) is a rare disorder characterized by the combination of two or more classic features: Fibrous dysplasia of bone, café-au-lait skin macules and hyperfunctioning endocrinopathies. Bisphosphonates are commonly administered in these patients to mitigate bone lesions and relieve pain; despite the benefits of this medication, its use places patients at risk for medication-related osteonecrosis of the jaws (MRONJ) making it essential to obtain a thorough medical history prior to any oral surgical procedure. The aim of this study was to present a rare case of MRONJ in a 29-year-old female patient with MAS, who had been receiving intravenous zoledronate for seven years and was submitted to the upper right impacted third molar removal. MRONJ remains a challenging condition with no standardized treatment protocol. In the present case, bone sequestrum removal combined with Platelet-Rich Fibrin and buccal fat pad grafting, along with pentoxifylline and tocopherol therapy, yielded positive outcomes.