N-acetylneuramic acid and 3ʹ-sialyllactose Supplementation Unlock Shared and Unique Atheroprotective Mechanisms through the Gut-Liver-Coronary Axis in Hypercholesterolemic LDLR⁻/⁻ Mice

Wei Zhang; Lin-Lin Zhou; Xinyuan Huang; Xinning Zhao; Wenqing Bo; Dong Bei Guo; Xiaoxuan Chen; Lili Pan; Hongwei Li

doi:10.1039/d5fo04031k

January 1, 2025Food & Function

N-acetylneuramic acid and 3ʹ-sialyllactose Supplementation Unlock Shared and Unique Atheroprotective Mechanisms through the Gut-Liver-Coronary Axis in Hypercholesterolemic LDLR⁻/⁻ Mice

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Key Points

Supplementation with N-acetylneuraminic acid effectively attenuates atherosclerosis in hypercholesterolemic mice, indicating its potential benefit.
Key measures reveal that both sialic acid and its derivative could uniquely influence cardiovascular health and gut-liver connections.
The investigation employed models of hypercholesterolemia to assess the impact of various supplements on atheroprotective pathways.
These findings highlight the importance of dietary components like sialic acid in developing strategies for cardiovascular health.

Implication

Supplementation improves atheroprotective mechanisms in hypercholesterolemic mice, suggesting sialic acid may play a crucial role.

Abstract

Background: Atherosclerosis remains a major global health burden. Sialic acid (N-Acetylneuraminic acid, Neu5Ac) and its derivative 3ʹ-sialyllactose (3'-SL) show potential for prevention, but their mechanisms of action are unclear. This...

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/692e3d796c9b3ab28c187199 https://doi.org/10.1039/d5fo04031k

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N-acetylneuramic acid and 3ʹ-sialyllactose Supplementation Unlock Shared and Unique Atheroprotective Mechanisms through the Gut-Liver-Coronary Axis in Hypercholesterolemic LDLR⁻/⁻ Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

N-acetylneuramic acid and 3ʹ-sialyllactose Supplementation Unlock Shared and Unique Atheroprotective Mechanisms through the Gut-Liver-Coronary Axis in Hypercholesterolemic LDLR⁻/⁻ Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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