Association of body roundness index with cardiovascular disease in early Cardiovascular-Kidney-Metabolic syndrome stage 0–3: mediation by the triglyceride-glucose index in a national cohort study

BRI positively linear associated with CVD, especially in early CKM syndrome population. Insulin resistance mediated the BRI-CVD association. The findings highlight BRI's potential for early risk stratification and the multifactorial pathophysiology linking adiposity to CVD.