The composite index TyG+BRI was associated with the highest risk of incident cardiovascular disease (HR 1.773) in Chinese middle-aged and older adults.
Cohort (n=7,853)
Yes
Do elevated triglyceride glucose index (TyG) and body roundness index (BRI) increase the risk of incident cardiovascular disease in Chinese middle-aged and older adults?
The combination of triglyceride glucose index and body roundness index significantly predicts incident cardiovascular disease risk, highlighting the interplay between insulin resistance and visceral adiposity.
Effect estimate: HR 1.773 (95% CI 1.499-2.097)
In conclusion, our study highlights the critical role of BRI as a mediator in the relationship between TyG and CVD risk. The findings indicate that both baseline and follow-up BRI significantly contribute to the pathway linking TyG to CVD, suggesting that individuals with higher BRI are at an increased risk. The antagonistic interaction underscores the complexity of metabolic risk factors in CVD development and emphasizes the need for a multifaceted approach in risk assessment and management. Future research should focus on elucidating the biological mechanisms underlying this interaction and exploring potential interventions that target body composition and metabolic health to mitigate CVD risk in high-risk populations.
Gu et al. (2026) conducted a cohort in Cardiovascular disease risk (n=7,853). Composite index TyG+BRI vs. Lower levels or individual indexes was evaluated on Incident cardiovascular disease (coronary heart disease or stroke) (HR 1.773, 95% CI 1.499-2.097). The composite index TyG+BRI was associated with the highest risk of incident cardiovascular disease (HR 1.773) in Chinese middle-aged and older adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: