What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial, RCT).

December 2, 2025Infection and ImmunityOpen Access

A retrospectively registered pilot randomized controlled trial of postbiotic administration during antibiotic treatment increases microbiome diversity and enriches health-associated taxa

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Microbiome diversity increased by 40% in patients receiving postbiotics alongside antibiotics.
Analysis of 157 fecal samples revealed significant enrichment of Lactobacillus strains in the treated group, compared to placebo.
This single-center randomized placebo-controlled trial involved 32 patients and assessed gut health post-treatment.
Findings suggest postbiotics may mitigate antibiotic-induced microbiome injury for improved health outcomes.

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Implication

Pilot trial shows improved microbiome diversity during antibiotic treatment in hospitalized patients, indicating postbiotics could benefit gut health.

Cite This Study

Schlüter et al. (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c18769d https://doi.org/10.1128/iai.00390-25

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Implication

Pilot trial shows improved microbiome diversity during antibiotic treatment in hospitalized patients, indicating postbiotics could benefit gut health.

A retrospectively registered pilot randomized controlled trial of postbiotic administration during antibiotic treatment increases microbiome diversity and enriches health-associated taxa

Key Points

Discussion

Implication

Cite This Study

A retrospectively registered pilot randomized controlled trial of postbiotic administration during antibiotic treatment increases microbiome diversity and enriches health-associated taxa

Key Points

Discussion

Implication

Cite This Study

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