Efficacy of Different Traditional Chinese Medicine Injections in the Treatment of Coronary Microvascular Disease: A Network Meta-Analysis

This study aims to compare the therapeutic efficacy of traditional Chinese medicine (TCM) injections in the treatment of coronary microvascular disease (CMVD) through a network meta-analysis. Multiple electronic databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and Chinese Biomedical Literature Database were retrieved up to November 15, 2023. The search was performed to identify randomized controlled trials (RCTs) on the therapeutic efficacy of TCM injections in combination with conventional Western medicine (CWM) for the treatment of CMVD. The Cochrane risk of bias tool was utilized to appraise the methodological quality of the included studies. Data analysis was performed using R software. A total of 13 RCTs, including 987 patients with CMVD, were included in the analysis. The results suggested that compared to CWM, Danhong [OR = 4.7, 95%CI (2.2, 11), P < 0.05] and Yiqi Fumai Lyophilized Injection [OR = 4, 95%CI (1.3, 14), P < 0.05] in combination with CWM demonstrated improved clinical efficacy in the treatment of CMVD. Danhong Injection [MD = −4.5, 95%CI (−6.4, −2.6), P < 0.05], Sulfotanshinone Sodium Injection [MD = −5.5, 95%CI (−7.1, −3.9), P < 0.05], Shuxuening Injection [MD = −7.9, 95%CI (−9.9, −5.9), P < 0.05], Shuxuetong Injection [MD = −4.4, 95%CI (−5.9, −2.9), P < 0.05], Ginkgo Leaf Extract and Dipyridamole Injection [MD = −3.6, 95%CI (−5.3, −2.0), P < 0.05], in combination with CWM, can reduce the frequency of angina attacks. TCM injections in combination with CWM are superior to CWM alone in the treatment of CMVD. However, further high-quality clinical research is needed to validate the above conclusion.