December 2, 2025The FASEB JournalOpen Access

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations

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Discussion

Fecal microbiota transplantations altered muscle phenotypes in wildtype mice, suggesting microbial therapy for muscular dystrophies.

Microbiota was linked to altered muscle health in dystrophic mice models.
Transplanting mdx microbiota induced muscle degeneration in wildtype mice.
Intra/inter-genotype fecal microbiota transplantations were conducted over a 9-week period.
Results suggest that microbes could be valuable therapeutic targets for muscular dystrophies.

Butcher et al. (2025) studied this question.

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