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December 2, 2025Haemophilia

Real‐World Data on Quality of Life in Relation to the Type of Prophylaxis in Polish Children With Haemophilia A—A Nationwide Study

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Authors

KPKlaudia PaczóskaAKAnna KlukowskaAKAleksandra Królak

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Overview

Nationwide analysis shows PK-guided prophylaxis significantly improves Quality of Life and bleeding control in haemophilia A patients.

Key Points

  • Switching to recombinant factor VIII resulted in significant bleeding control improvements, reducing annualised bleeding rates.
  • Overall Quality of Life improved significantly among children with haemophilia A after 26 weeks of pharmacokinetic-guided prophylaxis.
  • Assessment included 131 Polish boys with severe or moderate haemophilia A before and after changing their prophylactic treatment.
  • Results indicate that personalized pharmacokinetic approaches can enhance treatment outcomes and are worth integrating into standard care.

Cite This Study

Paczóska et al. (2025) studied this question.

synapsesocial.com/papers/692e3d986c9b3ab28c187b4ehttps://doi.org/10.1111/hae.70177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quality of Life in People With Haemophilia: Results in the Framework of a Nationwide Registry in Colombia2026
  2. 2Quality-of-Life Assessment and Pharmacokinetic Study in Hemophilia A Patients Undergoing Prophylactic Treatment2025 · 5 citations
  3. 3[Long-term health-related quality of life and related factors in children with severe hemophilia A who received regular low-dose prophylaxiss].2024
  4. 4Evaluation of Quality of Life in Children with Hemophilia2026
  5. 5Real-World Use of Extended Half-Life Factor IX in Children with Haemophilia B2025