December 2, 2025Journal of Evidence-Based MedicineOpen Access

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China

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Authors

JYJing‐Ping YunSun Yat-sen University YHYingyong HouSun Yat-sen University JCJieyu ChenNanjing University

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Implication

Observational analysis determined dmmr prevalence at 9.4% in chinese patients with advanced solid tumors, suggesting potential for immune checkpoint inhibition.

Key Points

Overall prevalence of dmmr was found to be 9.4% across different tumor types, with endometrial tumors showing the highest prevalence.
Patients with endometrial tumors had a dmmr prevalence of 29.9%, while cervical tumors showed only 2.7%.
Testing was performed using immunohistochemistry with the Ventana MMR RxDx panel to analyze dmmr status.
Importance of dmmr testing is highlighted for optimizing biomarker testing and treatment decisions for tumors in China.

Cite This Study

Yun et al. (2025) studied this question.

synapsesocial.com/papers/692e3da16c9b3ab28c187bf7 https://doi.org/10.1111/jebm.70081

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Implication

Observational analysis determined dmmr prevalence at 9.4% in chinese patients with advanced solid tumors, suggesting potential for immune checkpoint inhibition.

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China

Discussion

Member takes

Implication

Key Points

Cite This Study

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