Curcumin induces ferroptosis in hepatocellular carcinoma, suggesting therapeutic targets through P62-KEAP1-NRF2 signaling.
Our findings demonstrate that curcumin suppresses the P62-KEAP1-NRF2-signaling pathway to induce ferroptosis, a key mechanism underlying its anti-tumor effects. This study not only provides a novel scientific basis for the application of curcumin but also reveals potential therapeutic targets for hepatocellular carcinoma.
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Deng et al. (2025) studied this question.
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