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December 4, 2025Cancer ReportsOpen Access

Tumoral Stage of Mycosis Fungoides, Misdiagnosed With Wells Syndrome and Langerhans Cell Histiocytosis Histologically: A Challenging Case and Review of the Literature

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Authors

SVSeyed Mohammad VahabiSBSaeed BahramianAGAlireza Ghanadan

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Overview

Case report demonstrates chemotherapy and phototherapy improved tumoral stage mycosis fungoides in a patient, suggesting a need to rethink diagnostic challenges in similar cases.

Key Points

  • Tumoral stage mycosis fungoides improved significantly after chemotherapy and phototherapy, indicating effective treatment options.
  • The initial misdiagnosis included Langerhans cell histiocytosis and Well’s syndrome based on various biopsies showing eosinophile and histiocyte infiltration.
  • Assessment involved careful evaluation by dermatopathology and hematopathology specialists, revealing the complexity of the case.
  • This case highlights the diagnostic challenge of distinguishing between related disorders in cutaneous T-cell lymphoma.

Cite This Study

Vahabi et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1e00https://doi.org/10.1002/cnr2.70412
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management2022 · 98 citations
  2. 2Eosinophils in Mycosis Fungoides2012 · 35 citations
  3. 3Fulminant Mycosis Fungoides with Tissue Eosinophilia: A Unique Presentation of Two Cases with Acro-Periorbital Ulceration and An Aggressive Clinical Course2017 · 2 citations