December 4, 2025Advanced ScienceOpen Access

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

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Morphine-induced hyperactivity in mice is linked to the cingulate cortex and zona incerta.
Inhibition of the cingulate cortex-zona incerta pathway reduces hyperactivity linked to high-dose morphine.
The study identifies a pivotal role for delta-opioid receptors in mediating morphine's psychomotor effects.
Further exploration may optimize clinical outcomes related to opioid use while mitigating side effects.

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Experimental findings demonstrate morphine's effect on hyperactivity in mice, suggesting neural circuits may target clinical outcomes.

Shen et al. (2025) studied this question.

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