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December 4, 2025The Journal of Toxicological SciencesOpen Access

Renal effects of excessive fructose intake in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats

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Authors

KTKaoru ToyodaTTTadakazu TakahashiTSToshiyuki Shoda

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Overview

Investigative analysis shows nephropathy worsens in SDT fatty rats with high-fructose intake, indicating risks for obesity and diabetes-related kidney injury.

Key Points

  • High-fructose diet worsens nephropathy through increased urinary stone formation in diabetic models.
  • Histopathological examination revealed significant renal changes in SDT fatty rats after dietary intervention.
  • Assessment of renal health confirmed obesity and diabetes contribute to adverse effects on glomeruli function.
  • These findings may enable further exploration of dietary impacts on renal health in diabetic conditions.

Cite This Study

Toyoda et al. (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca2025https://doi.org/10.2131/jts.50.727
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