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December 4, 2025YAKUGAKU ZASSHIOpen Access

Analysis of Plastic Changes in Spinal Neurons in Fibromyalgia and the Exploration of Therapeutic Agents

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Observational analysis reveals sensory gating deficits in fibromyalgia, suggesting minocycline may alleviate symptoms.

Pathophysiology of fibromyalgia involves impaired sensory gating and heightened pain signaling.
In reserpine-induced fibromyalgia model rats, sensory gating deficits correlated with microglial activation and nociceptive transmission.
Analysis of dorsal root ganglia highlighted ASIC3 expression and mechanical hypersensitivity as key factors in pain processing.
Findings indicate that therapeutic agents like minocycline could play a role in treating fibromyalgia symptoms.

Daisuke Uta (2025) studied this question.

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