Isolation of 13‐residue peptaibiotics from marine‐derived fungus Acremonium persicinum and their underlying antifungal mechanisms against Botrytis cinerea

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Isolation of peptaibiotics shows effective antifungal activity against Botrytis cinerea, indicating their potential as fungicide alternatives.

Peptaibiotics reduced spore germination of Botrytis cinerea, demonstrating their antifungal efficacy.
Acting on fungicide-resistant strains, these compounds disrupt membrane integrity and increase reactive oxygen species levels.
Isolation used bioassay-guided methods, identifying potent antifungals while revealing their mechanisms of action.
Findings suggest that fungal metabolites may serve as promising candidates for bio-fungicide development, requiring further exploration.

Li et al. (2025) studied this question.

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Isolation of peptaibiotics shows effective antifungal activity against Botrytis cinerea, indicating their potential as fungicide alternatives.