December 4, 2025Military Medical ResearchOpen Access

β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

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Senescence of mesothelial cells is increased in peritoneal biopsy samples from long-term dialysis patients, impacting fibrosis risk.
Single-cell RNA sequencing highlighted critical pathways related to β-catenin in the senescence fate of mesothelial cells.
Treatment with senolytic drugs like dasatinib alleviated peritoneal fibrosis in mouse models, demonstrating therapeutic potential.
Targeting β-catenin signaling may help develop strategies to combat peritoneal fibrosis in end-stage renal disease.

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Implication

Single-cell RNA sequencing reveals β-catenin promotes senescence and myofibroblast activation in peritoneal dialysis, suggesting new therapeutic strategies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca222f https://doi.org/10.1186/s40779-025-00669-1

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Implication

Single-cell RNA sequencing reveals β-catenin promotes senescence and myofibroblast activation in peritoneal dialysis, suggesting new therapeutic strategies.

β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

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Discussion

Implication

Cite This Study

β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

Key Points

Discussion

Implication

Cite This Study

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