December 4, 2025Chinese Journal of Chemistry

Cascade Hydrothiolation and Hydroamidation of Alkynes to Regioselectively Afford 1,2‐Disubstituted Alkane Derivatives under Photocatalysis

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Regio-selective installation of N and S groups onto alkynes resulted in 1,2-disubstituted alkane derivatives.
Reactions leveraged photocatalysis yielding products under mild conditions with broad substrate scope.
A novel approach utilized triplet-triplet energy transfer and hydrogen atom transfer mechanisms to achieve transformation.
This method shows promise for synthesizing diverse alkanes while highlighting regio-selectivity in alkynes.

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Implication

Visible-light-mediated hydroamidation and hydrothiolation improve regioselectivity for alkynes, implying mild conditions enable new alkane derivatives.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca223a https://doi.org/10.1002/cjoc.70380

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Implication

Visible-light-mediated hydroamidation and hydrothiolation improve regioselectivity for alkynes, implying mild conditions enable new alkane derivatives.

Cascade Hydrothiolation and Hydroamidation of Alkynes to Regioselectively Afford 1,2‐Disubstituted Alkane Derivatives under Photocatalysis

Key Points

Discussion

Implication

Cite This Study

Cascade Hydrothiolation and Hydroamidation of Alkynes to Regioselectively Afford 1,2‐Disubstituted Alkane Derivatives under Photocatalysis

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider