The reaction demonstrates selective selenylation and sulfonylation in 1,7-dienes, suggesting a metal-free approach for divergent synthesis.
A metal‐free selective selenylation and sulfonylation of 1,7‐dienes with selenosulfonates for divergent synthesis of seleno‐/sulfonyl‐benzoxepines has been developed. This reaction was conducted under mild conditions without any catalysts, oxidants, or additives. The choice of solvent plays a crucial role in determining the formation of seleno‐/sulfonyl‐benzoxepines. Preliminary mechanistic studies suggest that both the selenylation and sulfonylation are accomplished through a selenyl radical and a sulfonyl radical cyclization process.
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Pan et al. (2025) studied this question.
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