This investigation reveals unique reactivity patterns in para-quinone monoacetals, suggesting new pathways for natural product synthesis and material sciences.
A concise synthetic route to the difluorinated para ‐quinone monoacetals ( p ‐QMAs) and their reactivity is described. Featuring a cross‐conjugated dienone core and an acetal unit, these compounds undergo diverse nucleophilic additions at the enone moiety and cycloadditions at the C═C bond. Such distinctive reactivity renders the β,β′‐difluoro p ‐QMA a versatile building block for the rapid assembly of complex molecular architectures, highlighting its promise in natural product synthesis and material sciences.
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Azami et al. (2025) studied this question.
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